Sevoflurane and cardioprotection
نویسندگان
چکیده
منابع مشابه
Cardioprotection with sevoflurane during off-pump coronary artery surgery
Methods Study included 48 patients induced in anesthesia with 8 vol.% sevoflurane within high 100% oxygen flow (5 L/min). Patients randomized into two groups: sevoflurane group (n = 24) in which anesthesia maintained with 1 MAC of endtidal sevoflurane concentration, and propofol group (n = 24), in which anesthesia maintained with continuous propofol infusion in doses of 2 to 3 mg/kg/h. Inclusio...
متن کاملPotential synergy of antioxidant N-acetylcysteine and insulin in restoring sevoflurane postconditioning cardioprotection in diabetes.
To the Editor: Drenger et al. have demonstrated that sevoflurane postconditioning is cancelled in the rat heart with type 1 diabetes mellitus and that this adverse effect by glucose intolerance cannot be restored by the adjustment of blood glucose using insulin. This study appears to have many questions regarding the mechanisms of insulin’s action, whereas we would congratulate their impressive...
متن کاملThe mechanism of sevoflurane-induced cardioprotection is independent of the applied ischaemic stimulus in rat trabeculae.
BACKGROUND Sevoflurane protects the myocardium against ischaemic injury through protein kinase C (PKC) activation, mitochondrial K+ATP-channel (mitoK+ATP) opening and production of reactive oxygen species (ROS). However, it is unclear whether the type of ischaemia determines the involvement of these signalling molecules. We therefore investigated whether hypoxia (HYP) or metabolic inhibition (M...
متن کاملWnt/Glycogen Synthase Kinase 3β/β-catenin Signaling Activation Mediated Sevoflurane Preconditioning-induced Cardioprotection
BACKGROUND Sevoflurane preconditioning (SP) has been shown to invoke potent myocardial protection in animal studies and clinical trials. However, the mechanisms underlying SP are complex and not yet well understood. We investigated the hypothesis that the cardioprotection afforded by SP is mediated via the Wnt/glycogen synthase kinase 3β (GSK3β)/β-catenin signaling pathway. METHODS Two models...
متن کاملCirculating microRNAs indicate cardioprotection by sevoflurane inhalation in patients undergoing off-pump coronary artery bypass surgery
In patients undergoing off-pump coronary artery bypass surgery (OPCAB), it is important to attenuate myocardium injury during the surgery. The present study aimed to observe the cardioprotection induced by sevoflurane induction and maintenance compared with propofol intravenous anesthesia, and to detect its potential protection against acute myocardial injury with sensitive biomarkers. In total...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2008
ISSN: 0007-0912
DOI: 10.1093/bja/aem381